Nina Dobrev & Ian Somerhalder
The Vampire Diaries pair was Hollywood's "It" couple from 2010 until their unfortunate break-up in 2013, though their characters continued dating on the show. Awkward?
Sophia Bush & Austin Nichols
Like their One Tree Hill characters, this duo sparked an IRL romance. Their relationship lasted four years before they broke it off in 2012.
Jessica Szohr & Ed Westick
After two years of dating on and off, this Gossip Girl pairing ended for good in 2010, probably because Chuck was still in love with Blair.
Candice King & Zach Roerig
2012 saw the end of this Vampire Diaries pair after a year of dating. The actress, then Candice Accola, started dating future husband Joe King of pop-rock band The Fray soon after.
Sophia Bush & Chad Michael Murray
These One Tree Hill co-stars found love outside of the show and tied the knot in 2005, before going their separate ways after just five months of marriage. The series continued airing until 2012.
Blake Lively & Penn Badgley
Now both married, these two once sparked a real-life romance while starring on Gossip Girl together. Theirthree-yearr relationship came to an end in 2010, but they remained castmates for two more seasons.
Leighton Meester & Sebastian Stan
Another Gossip Girl couple came and went after the onscreen Blair and Carter called it quits in 2010.
AnnaLynne McCord & Kellan Lutz
Back in 2009 this couple got cozy after the actor held a recurring role in 90210, but parted ways a year later.
Phoebe Tonkin & Paul Wesley
The four-year relationship between this Vampire Diaries duo recently came to an end in March of this year, though they were seen out holding hands again in May. Is there hope for this CW couple?